Chase has performed as a soloist recently with the New York Philharmonic, Los Angeles Philharmonic, San Francisco Symphony, Helsinki Philharmonic, BBC Scottish Symphony, Munich Chamber Orchestra, Kyoto Symphony, and London Philharmonia. In the 2022-23 season, Chase premiered a new duo concerto by Felipe Lara with the vocalist and bassist esperanza spalding and the conductor Susanna Mälkki, which was named one of the Best Classical Music Performances of the Year by The New York Times.

In 2013, Chase launched the 24-year commissioning project Density 2036, described by The New Yorker as "a quarter-century journey with little precedent." Now in its 12th year, Density reimagines the solo flute literature through commissions, performances, recordings, educational initiatives, and a community-focused approach to cultural production. Chase is the artistic director of Density Arts, a nonprofit organization dedicated to the advancement of the flute in the 21st century.

As an undergraduate at Oberlin Conservatory, Chase co-founded the International Contemporary Ensemble, earning the group multiple Chamber Music America/ASCAP Awards for Adventurous Programming and the Ensemble of the Year Award from Musical America Worldwide.
Chase is Professor of the Practice in the Department of Music at Harvard University and Creative Associate at The Juilliard School. She grew up in Leucadia, California.